Effects of Atropine on Brain Respiration.

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Abstract
Atropine inhibited the respiration of rat brain homogenates, the degree of inhibition decreases with decreasing pH in dilute buffered NaCl media. Acetylcholine had a negligible or slightly depressant effect when added to atropinized homogenates in this medium. In media containing substrates (glucose or alpha-glycerophosphate) and K ions acetylcholine antagonized the atropine effect. Ca appeared to be without influence on the action of either the atropine or acetylcholine. The absorption spectrum of atropine at various pH''s and constant ionic strength showed a depression of the max. at 245- 249 m[mu]. with decreasing pH, and corresponding to the decreased inhibitory action of the alkaloid at the same pH s.

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