Enzymic Oxidation α to the Acetylenic Group in the Metabolism ofN-(5-Pyrrolidinopent-3-ynyl)- Succinimide (BL 14)in vitro
- 1 January 1978
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 8 (6) , 341-348
- https://doi.org/10.3109/00498257809070017
Abstract
1. The product of α-acetylenic oxidation of N-(5-pyrrolidinopent-3-ynyl)-succinimide (BL 14) by rat liver preparations was identified as N-(5-pyrrolidino-2-hydroxypent-3-ynyl)succinimide, by mass spectral analysis of metabolites of deuterium-labelled and non-labelled substrate. 2. The synthesis and physicochemical characteristics of the metabolite are reported. 3. Substantial amounts of the metabolite were obtained in preparations from phenobarbital-treated rats, while only minute amounts were formed by non-induced preparations. 4. Evidence for the involvement of an inducible cytochrome P-450 system in effecting this α-acetylenic oxidation is presented.This publication has 11 references indexed in Scilit:
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