Effect of Oral Hypoglycemic Drug (Carbutamide) on Glycogen Deposition By Isolated Rat Hemidiaphragm

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Abstract
In the isolated rat hemidiaphragm Carbutamide, in contrast to insulin, does not stimulate glycogen deposition. In fact, Carbutamide in concentrations of 2 mg/2 ml significantly decreased the effect of 0.2 unit of insulin as measured by glycogen deposition. Sulfadiazine at this same concentration also reduced the insulin effect. This inhibition was not observed when 0.2 mg/2 ml of Carbutamide was used with insulin, nor was there any evidence of enhanced insulin action. These studies indicate that Carbutamide does not have an insulin-like effect on muscle and that at higher concentrations it may even be a non-specific protein poison.