IS OSMOTIC HEMOLYSIS AN ALL-OR-NONE PHENOMENON?

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Abstract
Hemolysis produced by hypotonic NaCl is of such a character that hemoglobin either fails to escape from the erythrocyte or does so completely up to the point permitted by the attainment of a diffusion equilibrium in the system; i.e., the hemolysis is of an all-or-none type. This has also been shown to be the case for hemolysis produced by penetrating substances, e.g., ethylene glycol and glycerol; and under conditions where, instead of permitting the hemolytic process to proceed to its final equilibrium position, it is stopped at an intermediate point by the addition of NaCl. These results give significance to the term "percentage hemolysis.".

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