Skin Reactions to 5-Fluorouracil

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Abstract
To the Editor: 5-Fluorouracil is a frequently used chemotherapeutic agent. The most common adverse reactions involve the gastrointestinal tract and bone marrow. Dermatologic reactions occur in 15 to 20 per cent of patients and are probably "nonallergic" since they are usually dose dependent.1 According to the package insert provided by the manufacturer (Roche) the most frequent dermatitis is a pruritic maculopapular rash, usually on the extremities but occasionally involving the trunk. Photosensitivity, hyperpigmentation and nail changes2 , 3 and, more recently, pigmentation along the course of veins4 have been described. We have frequently seen this last type of reaction in patients treated . . .

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