An Analysis of the Interaction of a Platinum Complex and Radiation with CHO Cells Using the Molecular Theory of Cell Survival
- 1 January 1976
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology
- Vol. 30 (6) , 511-524
- https://doi.org/10.1080/09553007614551371
Abstract
A mathematical analysis is developed from the concepts of the molecular theory of cell survival to explain the cytotoxic action of a platinum complex on CHO cells and its synergistic interaction with radiation. In the analysis, it is assumed that both inter- and intra-strand cross-links induced by the Pt complex in the DNA contribute to cell killing and that the synergistic effect arises from the interaction between an intra-strand cross-link and a radiation-induced single-strand break on complementary strands of the DNA. The analysis is shown to be compatible with experimental results. Further, a mechanistic model is developed in an attempt to explain in more detail the processes which appear to be involved in the expression of the cytological damage.This publication has 19 references indexed in Scilit:
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