Antithrombotic effect of a monoclonal antibody to the platelet glycoprotein IIb/IIIa receptor in an experimental animal model
Open Access
- 1 September 1986
- journal article
- Published by American Society of Hematology in Blood
- Vol. 68 (3) , 783-786
- https://doi.org/10.1182/blood.v68.3.783.783
Abstract
A murine monoclonal antibody directed at the platelet glycoprotein IIb/IIIa complex, which blocks platelet aggregation ex vivo, was tested for its antithrombotic effects in an established animal model of acute platelet thrombus formation in partially stenosed arteries. Infusion of 0.7 to 0.8 mg/kg of the F(ab')2 fragment of the antibody completely blocked new thrombus formation despite multiple provocations, making it the most potent antithrombotic agent tested in this model.Keywords
This publication has 0 references indexed in Scilit: