Experimental Research on IGF‐1
- 1 April 1986
- journal article
- Published by Wiley in Acta Paediatrica
- Vol. 75 (s325) , 107-111
- https://doi.org/10.1111/j.1651-2227.1986.tb10376.x
Abstract
IGF-1 has been produced by recombinant DNA technology; the host cell is a yeast. Studies in hypophysectomized rats show that IGF-1 has little growth promoting effect unless given by infusion at high doses, and priming with bovine growth hormone did not produce any potentiation. In vitro studies reveal that IGF-1 cross-reacts with the insulin receptor on adipose cells. Immunohistochemical studies have revealed high IGF-1 immunoreactivity in proliferating and differentiating cells in the testes, lymphoid organs and pancreatic islets and particularly in regenerating nerves. Local application of IGF-1 may stimulate regeneration in damaged peripheral nerves. Key words:Keywords
This publication has 8 references indexed in Scilit:
- Evidence indicating trophic importance of IGF‐1 in regenerating peripheral nervesActa Physiologica Scandinavica, 1986
- Localizator! of IGF‐I in adult rats. Immunohistochemical studiesActa Physiologica Scandinavica, 1986
- SOMATOMEDIN C IN PATHOGENESIS OF MALIGNANT EXOPHTHALMOS OF ENDOCRINE ORIGINThe Lancet, 1986
- Comparison of in vivo effects of insulin-like growth factors I and II and of growth hormone in hypophysectomized ratsActa Endocrinologica, 1985
- The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor.Journal of Biological Chemistry, 1982
- Insulin-like growth factor I stimulates growth in hypophysectomized ratsNature, 1982
- EFFECT OF GROWTH HORMONE AND PEPTIDE FRACTIONS CONTAINING SOMATOMEDIN ACTIVITY ON GROWTH AND CARTILAGE METABOLISM OF SNELL DWARFMICEActa Endocrinologica, 1979
- The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin.Journal of Biological Chemistry, 1978