Antiviral 9-[2-(phosphonomethoxy)alkoxy]purines
- 1 August 1991
- journal article
- Published by SAGE Publications in Antiviral Chemistry and Chemotherapy
- Vol. 2 (4) , 229-241
- https://doi.org/10.1177/095632029100200404
Abstract
9-[2-(Phosphonomethoxy)alkoxy]purines have been prepared and evaluated as antiviral agents. These compounds are the first reported acyclonucleotides in which an acyclic phosphonic acid-bearing substituent is attached to N-9 of a purine via a nitrogen-oxygen bond. Some 2-(phosphonomethoxy)ethoxy derivatives, e.g. (24), (25) and (27), have potent activity against herpesviruses. Some 3-hydroxy-2-(phosphonomethoxy)propoxy derivatives, e.g. (23) and (34), and a cyclic phosphonate (35), are potent and selective inhibitors of the replication of visna virus, a retrovirus.Keywords
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