The properties of tablets manufactured on an automatically-controlled rotary machine

Publisher Website
Google Scholar
Abstract
Four direct-compression bases: Celutab in the hydrous and the anhydrous form, Emcompress Special, and spray-dried lactose, have been compared with a traditional lactose granulation with respect to initial physical properties of the powder, tabletting performance and the characteristics of the tablets produced. The tablets were made on an instrumented rotary machine with feedback weight control operating to minimize time-dependent change within a batch, compression force being continuously monitored. Tensile strength by diametral crushing, porosity, disintegration time and surface indentation hardness were assessed and correlated with changes in compaction force, machine speed and tablet thickness. All materials gave wellformed tablets with no evidence of capping between 90 and 350 MN m−2, and weight variation was small except for Emcompress Special at the highest machine speed, when die filling became erratic.

This publication has 5 references indexed in Scilit: