Tumor Induction by Plastic Films: Attempt to Correlate Carcinogenic Activity With Certain Physicochemical Properties of the Implant2

Publisher Website
Google Scholar
Abstract
Forty-eight young-adult CB Wistar rats received a subcutaneous implant of 1 of 3 polyelectrolyte complex films of defined physicochemical properties: These films contained an excess of polyanions (‘anionic films’), an excess of polycations (‘cationic films’), or equal proportions of polyanions and polycations (‘neutral films’). Incisions were made in the flanks of 16 control rats, but film was not inserted. Local tumors were found in each of the 3 test groups, but not in the control group. The incidence rate of local tumors was less for implants of neutral film than for implants of the 2 non-neutral films. In the two latter groups, the incidence rate of local tumors was greater in animals bearing implants of cationic films. Differences were also found in the local tissue responses evoked by the 3 types of plastic: General reactive changes were less marked in connective tissue capsules enclosing neutral films, and ectopic calcification was frequently found near anionic and cationic films, but not near neutral films. Some sarcomas associated with cationic and anionic films were osteogenic. The findings are discussed in relation to the general problem of tumor induction by implanted plastics.

This publication has 0 references indexed in Scilit: