Highly enantioselective alkylation of carbon–nitrogen double bonds. Catalytic and stoichiometric asymmetric synthesis of optically active amines by the enantioselective addition of dialkylzinc reagents to N-diphenylphosphinoylimines
- 1 January 1992
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 16,p. 1097-1098
- https://doi.org/10.1039/c39920001097
Abstract
The first highly enantioselective alkylation of carbon–nitrogen double bonds (of N-diphenylphosphinoylimines) with dialkylzinc reagents promoted by chiral amino alcohols afforded optically active phosphoramides (precursors of amines) in up to 91% enantiomeric excess.Keywords
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