EFFECT OF UPTAKE INHIBITORS ON DEPLETION OF BRAIN NOREPINEPHRINE AND SEROTONIN AFTER ALPHA-METHYL-M-TYROSINE ADMINISTRATION TO RATS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 234  (2) , 229-235
Abstract
The depletion of brain norepinephrine (NE) after .alpha.-methyl-m-tyrosine injection into rats was antagonized by pretreatment with an uptake inhibitor (protriptyline or chlorimipramine) but was not completely prevented. Administration of protriptyline after .alpha.-methyl-m-tyrosine injection, at a time when NE was depleted, partially reversed the depletion. Serotonin depletion after .alpha.-methyl-m-tyrosine was not altered by pretreatment with fluoxetine, an inhibitor of uptake into serotonin neurons. Apparently part of the NE (but not serotonin) depletion occurring after .alpha.-methyl-m-tyrosine injection was due to the action of amine products that entered the NE neuron via the membrane uptake pump and whose presence within the nerve terminals was maintained by the uptake pump.

This publication has 0 references indexed in Scilit: