Validity of an enzyme immunoassay for detection of Neisseria gonorrhoeae antigens

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Abstract
An enzyme immunoassay (EIA; Gonozyme, Abbott Laboratories) for the antigenic detection of Neisseria gonorrhoeae in endocervical or urethral specimens was evaluated. EIA results were compared with results of conventional culture tests for N. gonorrhoeae. Specimens from 208 males (113 culture positive) and 252 females (72 culture positive) were tested. The sensitivity and specificity of EIA for specimens from males were 97.3 and 95.8%, respectively. The sensitivity and specificity of EIA for specimens from females were 79.2 and 87.2%, respectively.