Chlamydia pneumoniae community-acquired pneumonia: A review of 62 hospitalized adult patients
- 1 March 1996
- journal article
- research article
- Published by Springer Nature in Infection
- Vol. 24 (2) , 109-114
- https://doi.org/10.1007/bf01713313
Abstract
In a prospective study,Chlamydia pneumoniae was identified as the etiological agent in 62 (17.9%) of 346 adult patients hospitalized over the course of one year for community-acquired pneumonia at the Soroka Medical Center in Beer-Sheva, Israel. The diagnosis ofC. pneumoniae infection was based on serological testing of antibodies by the MIF technique. In 43 of these patients (69.4%), at least one other etiological agent, in addition toC. pneumoniae for community-acquired pneumonia was identified.Streptococcus pneumoniae was identified in 34 patients withC. pneumoniae (54.8%), as an additional causative factor in infection. Community-acquired pneumonia patients withC. pneumoniae were significantly older than non-C. pneumoniae patients (p=0.03), had a higher APACHE II score on admission (pC. pneumoniae infection recovered, despite treatment which is not considered to be specific forC. pneumoniae. It was concluded thatC. pneumoniae is a common etiological agent for community-acquired pneumonia in our region, particularly in the elderly, and is characterized by a high rate of concomitant infections with other pulmonary pathogens. No specific clinical or radiological pattern was discerned that could distinguish betweenC. pneumoniae community-acquired pneumonia and non-C. pneumoniae community-acquired pneumonia. Unter 346 im Rahmen einer prospektiven Studie erfaßten Patienten mit ambulant erworbener Pneumonie fanden sich 62 Fälle (17,9%), bei denenChlamydia pneumoniae als der verantwortliche Erreger identifiziert wurde. Die Studie lief über einen Zeitraum von einem Jahr am Soroka Medical Center in Beer-Sheva, Israel. Die Diagnose basierte auf dem serologischen Nachweis von anti-C. pneumoniae Antikörpern mit der MIF-Technik. Bei 43 dieser Patienten fand sich mindestens noch ein zusätzlicher Erreger (69,4%). Bei 34 Patienten wurdeStreptococcus pneumoniae isoliert (54,8%). Patienten mit einerC. pneumoniae-Infektion waren signifikant älter als Patienten, bei denenC. pneumoniae nicht der Erreger war (p=0,03), diese Patienten hatten außerdem bei Einweisung einen höheren APACHE Score (pC. pneumoniae Pneumonie erkrankt waren. Wir schließen aus den Daten, daßC. pneumoniae in unserer Region ein häufiger Pneumonieerreger ist, der vorwiegend ältere Personen befällt. Typischerweise besteht eine hohe Rate an Begleitinfektionen mit anderen Pneumonieerregern. Wir fanden kein spezifisches radiologisches Muster oder klinische Konstellationen, die eine Unterscheidung zwischenC. pneumoniae-Pneumonie und Pneumonien anderer Ätiologie ermöglichen würden.Keywords
This publication has 28 references indexed in Scilit:
- Chlamydia pneumoniae-Induced Ciliostasis in Ciliated Bronchial Epithelial CellsThe Journal of Infectious Diseases, 1995
- Use of Serology to Diagnose Pneumonia Caused by Nonencapsulated Haemophilus influenzae and Moraxella catarrhalisThe Journal of Infectious Diseases, 1994
- Incidence of community-acquired pneumonia caused byChlamydia pneumoniae in Italian patientsEuropean Journal of Clinical Microbiology & Infectious Diseases, 1993
- Regional Differences of Chlamydia pneumoniae as Causative Agent of Pneumonia in SwedenScandinavian Journal of Infectious Diseases, 1992
- Pneumolysin, produced in Bacillus subtilis as antigen in enzyme immunoassay for etiological diagnosis of pneumococcal pneumoniaSerodiagnosis and Immunotherapy in Infectious Disease, 1990
- Demonstration of pneumolysin antibodies in circulating immune complexes—a new diagnostic method for pneumococcal pneumoniaSerodiagnosis and Immunotherapy in Infectious Disease, 1990
- New and Emerging Etiologies for Community-Acquired Pneumonia with Implications for TherapyMedicine, 1990
- Diagnosis ofMycoplasma pneumoniae infection by microparticle aggluination and antibody-capture enzyme-immunoassayEuropean Journal of Clinical Microbiology & Infectious Diseases, 1990
- Measurement of antibody responses to pneumolysin-A promising method for the presumptive aetiological diagnosis of pneumococcal pneumoniaJournal of Infection, 1989
- Preliminary Serologic Evidence for a Pathogenic Role of Branhamella catarrhalisThe Journal of Infectious Diseases, 1981