Effect of increased knee joint pressure on oxygen tension and blood flow in subchondral bone

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Abstract
The influence of acute changes in the knee joint pressure of rabbits on the O2 tension and the regional blood flow in the subchrondral bone was investigated. The intra-articular pressure was increased by infusion of a NaCl solution into the joint cavity, and the associated change in the subchondral O2 tension was measured by mas spectrometry. Mass spectrometry was used to detect qualitative changes in the regional blood flow. When joint pressure was increased from the habitual level to 75 mm Hg, the average subchrondral O2 tension was reduced from .apprx. 39 to .apprx. 30 mm Hg and, at the same time, the regional blood flow was reduced significantly.