A STUDY OF HUMAN THYROID FUNCTION BY MEANS OF RADIOACTIVE IODINE

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Abstract
SUMMARY: 1. When the state of the thyroid is classified as euthyroid or hyperthyroid from a previous estimation of clinical symptoms, B.M.R. and plasma-bound iodine concentration (P.B.I.), there is no appreciable overlap in either the maximum uptake, the time to reach the maximum, or in the mean rate of iodine accumulation by the thyroid, during the first 3 hr following oral administration of 100 μc. 131I. 2. The line of demarcation between the hyperthyroid and the euthyroid lies at a maximum uptake of 40% of the administered dose or at a maximum average rate of accumulation of 6%/hr during the first 3 hr. 3. The rate of disappearance of iodine from the blood is not so sharply defined in the two groups. In the euthyroid group it varies from 8 to 19%/hr, while in the hyperthyroid it ranges between 16 and 34%/hr.

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