THE INFLUENCE OF DIET UPON UREA CLEARANCE IN DOGS

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Abstract
Casein after repeated acid precipitation was almost as effective per gm. of protein in elevating post-absorptive and post-prandial urea clearance in dogs, as meat. Glycine, synthesized glyc-ine, d-l alanine and glutamic acid were very effective in elevating post-prandial urea clearance. Lactic acid, pyruvic acid, glycolic acid and deaminated glycine were approximately as effective as the corresponding amino acids. Therefore, the effect of protein on urea excretion was not necessarily due to deaminization. Fatty acids such as acetic and propionic elevated urea clearance. Gluconic acid, which was not metabolized by animal tissues did not elevate urea clearance. Butter, when added to a meal of starch and Crisco, increased the average urea clearance 45%, but additional Crisco had little effect. The non-saponifiable matter of butter when fed with starch and Crisco increased the average urea clearance 27% and when fed with 50 gm. of Crisco increased the average clearance 57%.