Biphasic effects of a potent enkephalin analogue (d-Met2,Pro5)-enkephalinamide and morphine on locomotor activity in mice
- 1 December 1980
- journal article
- research article
- Published by Springer Nature in Psychopharmacology
- Vol. 71 (3) , 299-301
- https://doi.org/10.1007/bf00433065
Abstract
The effects of morphine and a potent enkephalin analogue on spontaneous locomotion have been compared in mice. In doses of 3–10 mg/kg SC both compounds induced a brief reduction of motor activity followed by a period of behavioral hyperactivity. Similar receptorial mechanisms are suggested in mediation of their motor effects.Keywords
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