To Be or Not to Be...Ubiquitinated?
- 1 February 2004
- journal article
- Published by Taylor & Francis in Cell Cycle
- Vol. 3 (2) , 136-138
- https://doi.org/10.4161/cc.3.2.659
Abstract
Levels of p21, a cyclin-dependent kinase (CDK) inhibitor, are controlled in part at the post-translational level by protein degradation. Although the signaling pathways leading to p21 degradation have not yet been fully elucidated, it is evident that p21 ubiquitination is an essential factor in its degradation. We discuss that, with the only notable exception of ornithine decarboxylase, ubiquitination appears a prerequisite for proteasomal degradation rather than an unnecessary byproduct of such proteolysis.Keywords
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