TREATMENT OF NEPHROSIS WITH CONCENTRATED HUMAN SERUM ALBUMIN. II. EFFECTS ON RENAL FUNCTION AND ON EXCRETION OF WATER AND SOME ELECTROLYTES 123

Open Access
Publisher Website
Google Scholar
Abstract
20 courses of albumin (50 g./day for 3-6 days) were given to 13 cases of nephrosis, resulting in elimination of edema in 5 cases and variable losses of fluid in the remainder. The sequence of events seems to be: (1) increased colloid osmotic pressure of plasma, (2) dilution of the plasma to nearly the original plasma protein concn., (3) increased glomerular filtration rate, (4) increased excretion of water, (5) increased serum sodium concn. Further diuresis is limited by Na excretion which reaches maximum levels on the second or a later day. Various factors which affect Na excretion are examined, but the most important appear to be the glomerular filtration rate and the tubular Na reabsorption under the control of the adrenal cortex.