Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function
- 27 October 1994
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 371 (6500) , 762-767
- https://doi.org/10.1038/371762a0
Abstract
The cloning is described of two related human complementary DNAs encoding polypeptides that interact specifically with the translation initiation factor elF-4E, which binds to the messenger RNA 5'-cap structure. Interaction of these proteins with elF-4E inhibits translation but treatment of cells with insulin causes one of them to become hyperphosphorylated and dissociate from elF-4E, thereby relieving the translational inhibition. The action of this new regulator of protein synthesis is therefore modulated by insulin, which acts to stimulate the overall rate of translation and promote cell growth.Keywords
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