Studies on arsenic metabolism (XVII). Studies of placental transfer and antidotes and diets on placental transfer

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Abstract
Albino rats of Wistar strain bred in a closed colony were administered AsO3 orally during pregnancy (0-20th day). Organs of fetuses and mother rats were exenterated on the 21st day of gestation and As measured using atomic absorption spectrophotometry. Whole organs of the fetus were separated into 3 groups, i.e., liver, brain and remaining organs. The As content in each group and in the placenta were measured. Even in the non-administered group, As was detected in every organ. In the As administered group, the content of As in the placenta was the highest among the 4 preparations tested. The content in the liver and remaining organs was high, but was low in the brain. The As level differed in each organ. In the placenta the accumulation reached a plateau. The brain accumulation was less than 1/10 that of the liver. In the non-administered group, As was detected in the liver, kidney, spleen and brain of mother rats. In the group on As, the content in the kidney and spleen was high followed by a large amount in the liver and in the brain, respectively. The level of accumulation of As in mother rats differed in each organ. As was administered with antidotes such as dimercaprol, thioctic acid and L-ascorbic acid during pregnancy (0-5th day). In this group As in the remaining organs was statistically less than that of the control group. The content in the brain was slightly reduced by a co-administration of the antidotes; however, there was no statistical difference in the placenta and liver between the antidote-treated and control groups. The As content in the kidney of mother rats treated with antidotes was statistically less than that of the controls. Whether or not the As content in organs of fetuses and mother rats was affected by a milk diet was also studied. No statistical difference between the animals on an Oriental stock diet group and those on the milk diet was found. The As content in the kidney of mother rats on the milk diet was statistically less than the Oriental stock diet group.

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