Metallation of pyridine N-oxides and application to synthesis
- 1 January 1995
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 19,p. 2503-2508
- https://doi.org/10.1039/p19950002503
Abstract
Regio- and chemi-selective, directed ortho-lithiation of 2-, 2,5- or 3,4-substituted pyridine N-oxides has been achieved with diisopropylamide and butyllithium. Polysubstituted pyridine N-oxides, azaxanthone, and an isomer of orelline have been synthesized by such methods.Keywords
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