HEMOSTATIC BALANCE ALTERATIONS IN OBESE CHILDREN

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Abstract
Fibrinolytic response to venous occlusion and other clotting parameters was studied in 34 obese children and 16 controls. The obese children (mean age 9 1/6) had a mean overweight of 51.8% .+-. 15.6, higher blood glucose and cholesterol levels, and increased baseline and glucose-induced insulinemia. Baseline ELT [euglobulin lysis time] did not differ significantly. ELT after 5 min venous occlusion was 203.2 .+-. 110.9 min in the obese children and 114.7 .+-. 67.9 min in the control group (P < 0.01) with a mean percent decrease, respectively, of 14.9 and 29.2%. Poor fibrinolytic responders did not correlate with age, overweight or metabolic indices. Lower levels of ATIII[antithrombin III] (P < 0.01) and no changes in FVIII: C [hemocoagulative determination of factor VIII] and F VIII: R Ag [immunologic determination of factor VIII] were found in the obese. In a larger group of 84 prepubertal obese children (mean age 10 yr; mean overweight 48.2%) and in 39 normal prepubertal children (mean age 10 1/3 yr) platelet aggregation capacity was studied according to Breddin. This parameter was altered in a high proportion of the obese children (P < 0.05). The obese children were poor fibrinolytic responders, similarly to obese adults, and exhibited early alteration of clotting balance.