Additional Evidence as to the Intercellular Formation of Connective Tissue

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Abstract
The testes of guinea pigs were inoculated with living tubercle bacilli. Studies of sections show that the result is an almost complete degeneration and elimination of the germinal cells from the seminiferous tubules, and the appearance of an abundant exudate in the intertubular areas of the testis. Varying degrees of cellular infiltration may occur in these areas, but frequently large areas of exudate are practically cell free when first observed. The exudate is at first quite homogeneous or with a fine fibrillation but gradually this material is transformed into a typical fibrous tissue, together with the formation of heavy bundles of wavy fibers which stain typically with a Mallory stain. The transformation is not dependent on direct cellular connections and appears to be identical with the process by which connective tissue is developed in frog and chick embryos.

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