Successful treatment of an advanced interstitial pregnancy by sequential systemic and local administration of methotrexate
- 1 July 1995
- journal article
- research article
- Published by Oxford University Press (OUP) in Human Reproduction
- Vol. 10 (7) , 1864-1865
- https://doi.org/10.1093/oxfordjournals.humrep.a136193
Abstract
A patient is presented with an advanced interstitial pregnancy, diagnosed by transvaginal ultrasound and confirmed by laparoscopy. Amenorrhoea at the time of diagnosis was 57 days. Methotrexate was given systemically (4×50 mg i.m.). Because of persisting viability of the fetus, systemic methotrexate treatment was followed by local instillation of methotrexate into the gestational sac (50 mg). Follow-up revealed rapid human chorionic gonadotrophin regression but slow regression of fetal remnants.Keywords
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