Adrenocortical Response to Novelty and Noxious Stimulation

Abstract
Rats were either subjected to high levels of electric shock or merely placed in the experimental cage for a comparable period of time. The experiment was conducted at the "peaks" and "troughs" of the adrenocortical circadian rhythm. The plasma corticosterone levels did not differ significantly in these 2 groups of rats, though both had significantly higher corticosterone levels than control animals. The data demonstrate that exposure to a new environment, or novelty, may contribute significantly to the adrenocortical response often attributed entirely to the effects of noxious or painful stimulation.

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