Next-Generation Optical Technologies for Illuminating Genetically Targeted Brain Circuits
Top Cited Papers
Open Access
- 11 October 2006
- journal article
- review article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 26 (41) , 10380-10386
- https://doi.org/10.1523/jneurosci.3863-06.2006
Abstract
Emerging technologies from optics, genetics, and bioengineering are being combined for studies of intact neural circuits. The rapid progression of such interdisciplinary “optogenetic” approaches has expanded capabilities for optical imaging and genetic targeting of specific cell types. Here we explore key recent advances that unite optical and genetic approaches, focusing on promising techniques that either allow novel studies of neural dynamics and behavior or provide fresh perspectives on classic model systems.Keywords
This publication has 41 references indexed in Scilit:
- Light Activation of Channelrhodopsin-2 in Excitable Cells of Caenorhabditis elegans Triggers Rapid Behavioral ResponsesCurrent Biology, 2005
- Fast noninvasive activation and inhibition of neural and network activity by vertebrate rhodopsin and green algae channelrhodopsinProceedings of the National Academy of Sciences, 2005
- Use of Herpes Virus Amplicon Vectors to Study Brain DisordersBioTechniques, 2005
- Labeling neurons in vivo for morphological and functional studiesCurrent Opinion in Neurobiology, 2004
- In Vivo Multiphoton Microscopy of Deep Brain TissueJournal of Neurophysiology, 2004
- Channelrhodopsin-2, a directly light-gated cation-selective membrane channelProceedings of the National Academy of Sciences, 2003
- Multiphoton endoscopyOptics Letters, 2003
- Photochemical gating of heterologous ion channels: Remote control over genetically designated populations of neuronsProceedings of the National Academy of Sciences, 2003
- Selective Photostimulation of Genetically ChARGed NeuronsNeuron, 2002
- COMPARISON OF THE EFFECTS OF UNILATERAL AND BILATERAL EYE CLOSURE ON CORTICAL UNIT RESPONSES IN KITTENSJournal of Neurophysiology, 1965