The in vitro effect of a calf thymus extract on the peripheral blood lymphocytes of patients with warts

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Abstract
T [thymus-derived] and B [bone marrow-derived] lymphocyte populations were evaluated in 41 patients with multiple recurring warts. Active [erythrocyte] rosettes (T-Ea) and total T lymphocytes (T-Et) were significantly decreased. The in vitro effect of a calf thymus extract (TP-I) on peripheral blood lymphocytes was evaluated in 33 patients. A statistically significant increase in E-rosette forming cells was observed in 23 patients (69%). Serum blocking factors were not found in patients with a positive response to TP-I, which suggests a thymic hormone deficiency. In the case of non-responders to TP-I, an anti-lymphocyte antibody may directly block hormone receptors on the undifferentiated lymphocytes.