HETEROGENEITY OF NON-HODGKIN LYMPHOMA PROBED BY NUCLEIC-ACID CYTOMETRY

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  • 1 January 1985
    • journal article
    • research article
    • Vol. 65  (5) , 1090-1096
Abstract
Flow cytometric analyses of cellular DNA, RNA and double-stranded RNA content were performed on lymph nodes and extranodal tissue from 177 patients with non-Hodgkin''s lymphoma. With increasing histologic grade, a higher incidence of aneuploidy, higher proliferative activity, and higher total and double-stranded RNA content were found. Despite considerable cytometric heterogeneity within histologic grades and morphologic subdivisions, conformity between cytometric and morphologic classifications was observed in 85% of cases. Among intermediate-grade and high-grade lymphomas, increased proliferative activity and diploidy were associated with more frequent responses to treatment. Nucleic acid-derived parameters relate to morphologic subtypes and permit an objective approach to lymphoma classification based on ploidy, proliferation and RNA characteristics that also had prognostic implications.

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