The Cigarette Factor in Lung Cancer Due to Chloromethyl Ethers

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Abstract
In a prospective study of 51 men who had moderate to heavy cumulative occupational exposure to chloromethyl ethers, 11 developed lung cancer in a 16 yr period. The risk was higher in men who were not smoking cigarettes at the start of observation than in those who were. This difference was even more impressive when examined in relation to the risks of lung cancer by smoking habit in the general population. Continued cigarette smoking entailed a factor which partially inhibited the carcinogenic effect of chloromethyl ethers.

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