The Asymmetric Synthesis of (2R,3R)- and (2R,3S)-3-Methyl-aspartates via an Enantiodiscrimination Strategy

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Abstract
The enolate of (S)-N,N′-bis-(p-methoxybenzyl)-3-iso-propylpiperazine-2,5-dione exhibits high levels of enantiodiscrimination towards racemic 2-bromo-propionate esters of afford adducts containing two new stereogenic centers which may be deprotected to afford (2R,3R)-3-methyl-aspartates or epimerised and then deprotected to afford (2R,3S)-3-methyl-aspartates as single diastereoisomers in high e.e.

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