Serum galactosylhydroxylysyl glucosyltransferase in acute myocardial infarction and during subsequent collagen scar formation

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Abstract
Changes in serum galactosylhydroxylysyl glucosyltransferase, an enzyme catalyzing 1 of the intracellular post-translational modifications in collagen biosynthesis, were studied in 24 patients with acute myocardial infarction. The enzyme activity was monitored for 18 days from the onset of infarction, and at least a 2-peaked pattern was observed. The 1st peak corresponded to the stage of acute myocardial injury, there being a highly significant correlation between the maximal values for serum glucosyltransferase and .alpha.-hydroxybutyrate dehydrogenase. An average decrease in serum glucosyltransferase activity of 41% was noted during the following 24 h. A new gradual rise in serum glucosyltransferase activity, interpreted as indicating myocardial collagen scar formation, was observed 5 days after the onset of infarction, when the serum enzyme activities indicating myocardial injury had already declined. The average daily values for serum glucosyltransferase between 6 and 18 days correlated highly significantly with the maximal value for serum .alpha.-hydroxybutyrate dehydrogenase which serves as a relative estimate for the size of the original myocardial infarction area. Certain other factors including heart failure and/or various drug treatments may also affect the magnitude of this 2nd peak.