The effect of theophylline on thyrotoxic tremor.

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Abstract
1 The effects of intravenous aminophylline on theophylline-induced tremor were studied in six hyperthyroid patients before and after treatment to euthyroidism. 2 Baseline tremor power was significantly greater in the hyperthyroid compared with the euthryoid state (P < 0.05). 3 Aminophylline produced a significantly greater increase in tremor power in the hyperthyroid compared with euthyroid state. 4 There was a significant increase in plasma theophylline clearance and reduction in t1/2 elimination when patients were hyperthyroid but volume of distribution did not change. 5 Intravenous aminophylline potentiates the tremor produced in hyperthyroidism despite an increase in plasma theophylline clearance. A pharmacodynamic mechanism is therefore likely.