Inhibitory Effect of Dehydroevodiamine and Evodiamine on Nitric Oxide Production in Cultured Murine Macrophages
- 1 July 1997
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 60 (7) , 708-711
- https://doi.org/10.1021/np960495z
Abstract
Possible antiinflammatory effects of dehydroevodiamine (1) and evodiamine (2) were examined by assessing their effects on NO production in the murine macrophage-like cell line RAW 264.7. The results indicated that both 1 and 2 inhibited the IFN-γ/LPS-stimulated NO production in a concentration-dependent manner. However, 1 appeared to inhibit NO production by interfering not only with the priming signal initiated by IFN-γ but also with iNOS protein synthesis, while 2 affected the former only.Keywords
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