Tocopherol Deficiency in Man

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Abstract
THE pathophysiologic effects of vitamin E deficiency in man remain uncertain some forty years after isolation and purification of this vitamin. Although tocopherol depletion in infants and children with steatorrhea is well documented, no clear-cut clinical syndrome secondary to tocopherol deficiency is recognized.1 , 2 Certain in vitro phenomena of unknown physiologic significance have been noted, however.1 2 3 This report describes some observations on a group of patients in whom vitamin E deficiency secondary to steatorrhea developed. Certain physiologic and morphologic changes secondary to tocopherol deficiency were evident and may be more extensive than those described previously in man.Materials and MethodsBlood . . .