Steroids Influencing the Toxicity of L-Tyrosine

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Abstract
In rats, the typical features of dietary tyrosine intoxication, including inflammatory changes in the eyes, pancreas, paws and snout, can be prevented not only by glucocorticoids (triamcinolone, prednisolone) but also by typical catatoxic steroids devoid of glucocorticoid potency. Among the latter PCN (pregnenolone-16α-carbonitrile), ethylestrenol, compound CS-1 (manufacturer's code number SC-11927), spironolactone, norbolethone and progesterone are efficacious. Estradiol has no glucocorticoid effect and is also devoid of catatoxic potency against other toxicants, yet, it likewise offers some protection against tyrosine intoxication. On the other hand, oxandrolone, desoxycorticosterone, hydroxydione and cholesterol are ineffective in this respect. Phenobarbital, a nonsteroidal catatoxic enzyme inducer, offers excellent protection against tyrosine intoxication, whereas thyroxine aggravates it.

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