EFFECT OF PHENCYCLIDINE AND KETAMINE ON SCHEDULE-CONTROLLED BEHAVIOR IN PIGEON

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 196  (1) , 172-179
Abstract
Pigeons were trained under a multiple schedule of food presentation with alternating 30-response fixed-ratio (FR-30) and 10-min fixed-interval (FI-10) components. Average rates of responding were 2.9 and 0.55 responses/s, respectively. Both phencyclidine (0.03-3.0 mg/kg i.m.) and ketamine (0.1-30.0 mg/kg i.m.) increased response rates at low doses while decreasing response rates at high doses during the FI-10 component. Only a dose-related decrease in response rates was seen in the FR-30 component with both phencyclidine (PCD) and ketamine (KT). In individual birds the maximum rate increases in the FI-10 component ranged from 110% to 163% of the control rate. The rate increases in the FI-10 component depended on the control rate of responding. The effects of PCD and KT were qualitatively similar to d-ampehtamine (0.1-10 mg/kg i.m.).

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