Effect of Sodium 5-Allyl-5-(1 methylbutyl) 2-Thiobarbiturate on Uptake of I131 by Rat Thyroid

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Abstract
Sodium-5-allyl-5-(l methylbutyl) 2-thiobarbiturate (Surital) reduced the incorporation of I131 into rat thyroid to 9.7% of control values. The proportion of recoverable I131 in the inorganic and organically bound fractions of thyroid alkaline hydrolysate is essentially the same for control and Surital-treated rats. This indicates the mechanism of inhibition to be similar to other antithyroid agents. This study suggests that clinical evaluation of thyroid status via I131 uptake should exclude previous treatment with the thiobarbiturate anesthetics.

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