MUSTARD CHEMOTHERAPY IN OVARIAN CARCINOMA

Publisher Website
Google Scholar
Abstract
Thirty-eight patients with various types of ovarian carcinoma were treated over a period of 6 years with the mustard compounds HN2,triethylenemelamine (TEM), and chlorambucil. The effect of previous therapy, the anatomic extent of the disease, and pathologic features of resected tissue were studied in reference to objective evidence of tumor regression. Results of chemotherapy were graded as excellent in 4 patients, good in 7, and fair in 6. The duration of favorable responses ranged from 4 months to over 6 years. Response to chemotherapy could not be evaluated in 6 patients. In 15 patients (40%), there was no evidence of anti-tumor effect. The therapeutic effect of different mustard compounds was qualitatively similar. For maximal and satisfactory suppression of the growth of ovarian carcinomas, continuous and aggressive therapy was invariably necessary.

This publication has 0 references indexed in Scilit: