Effects of Some Old and Proposed Anticonvulsants on the Threshold for Electrical Convulsions
- 1 February 1947
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 64 (2) , 245-248
- https://doi.org/10.3181/00379727-64-15758
Abstract
Over 400 tests were made in 210 animals (white rats and a few rabbits) with 23 different agents on the threshold for electrical convulsions. Of 3 new hydantoins studied, di-isobutyl-hydantoin was the most promising, being somewhat comparable to Na diphenylhydantoin in high doses. Among the ineffective agents were 4 drugs of the curare group, alleged central depressants, and 5 different dyes, including hematoxylin and vital red, alleged anti-epileptic agents.Keywords
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