Microglandular Hyperplasia in Cervical Cone Biopsies Taken for Suspicious and Positive Cytology

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Abstract
To determine the incidence of endocervical microglandular hyperplasia, a series of 128 consecutive cone biopsies taken because of suspicious or positive cytologic findings was examined. Microglandular hyperplasia was found in 24% of the total series and in 44% of those with histories of oral contraceptive pill use. Of the patients who had not taken oral contraceptives, only 11% had similar lesions, and half of these were pregnant, postpartum, or their contraceptive histories were unknown. It is concluded that microglandular hyperplasia is an end result of progesterone stimulation. The spotty distribution of the lesions would indicate variable local sensitivity of the tissues to progestational agents. The apparent persistence of the lesion after discontinuation of contraceptive pills implies that increased progesterone levels are necessary for induction only and not for maintenance of the lesion. There was no significant correlation of microglandular hyperplasia with age, cytologic atypia, or cone biopsy diagnosis.

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