The effect of anti-inflammatory drugs on the protein-binding of 11-hydroxysteroids in human plasma in vitro
- 1 July 1969
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 21 (7) , 451-459
- https://doi.org/10.1111/j.2042-7158.1969.tb08286.x
Abstract
The effect of acetylsalicylic acid, ibufenac, indomethacin, oxyphenbutazone and phenylbutazone on the protein-binding of 11-hydroxysteroids in vitro at concentrations in excess of normal has been examined in human blood bank plasma, in plasma from women in the third trimester of pregnancy, and in plasma from patients after injections of tetracosactide. Phenylbutazone, ibufenac and indomethacin do not significantly affect the protein-binding of 11-hydroxysteroids. Oxyphenbutazone causes a decrease in the proportion of unbound 11-hydroxysteroids and acetylsalicylic acid produces an increase of unbound 11-hydroxysteroids.Keywords
Funding Information
- Nuffield Foundation
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