DELAYED CONCENTRATION AND PROLONGED EXCRETION OF UROGRAPHIC CONTRAST MEDIUM IN THE FIRST MONTH OF LIFE

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Abstract
In infants in the first month of life, excretion of intravenously injected urographic contrast medium—in this case methylglucamine diatrizoate—is prolonged and maximum concentration appears to be achieved at approximately 1-3 hours after injection. This observation was confirmed by review and tabulation of 80 intravenous urograms in infants under the age of 1 month and 80 comparable studies of pediatric patients the age of 1-2 years, in all of whom no significant urinary tract abnormality had been demonstrated. The significance of this observation with reference to renal physiology is not clear, and in particular we do not as yet know to what extent prematurity may contribute to the difference in the excretion curve in the neonatal period as compared to older pediatric patients and adults. Visualization and interpretation of the urinary tract in the neonatal period can be greatly improved, by diminishing the number of early urograms after the intravenous injection of the contrast medium, and prolonging the examination to several hours when necessary.

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