Influence of Estrogen on Renal Function and Water Intake in Male Rabbits Rendered Polyuric-Polydipsic by Food Deprivation

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Abstract
These experiments were designed to test the possibilities that the estrogen inhibition of the polyuria-polydipsia of food-deprived male rabbits may be due to an effect on: 1) renal hemodynamics or renal tubular handling of water, and/ or 2) water ingestion. Glomerular nitration rates (CCr) and renal plasma flows (CPAH) were determined on trained rabbits during: 1) control (fed), 2) polyuric-polydipsic (food-deprived) and 3) inhibited polyuric-polydipsic (receiving 400 μg estradiol benzoate, EB) periods. To assess renal water handling, the response to a water load was studied. To evaluate changes in fluid ingestion, the 3-hr drinking response was measured following administration of 10% NaCl, by gavage. Estradiol was administered in varying doses 2 hr prior to the test. The timed drinking (6 hr) of food deprived rabbits with and without estrogen treatment was measured. The polyuria-polydipsia was not accompanied by changes in CCCr or PAH, nor did the estrogen alter these parameters while inhibiting the polyuria- polydipsia. Food deprivation induced an enhanced fluid exchange and significantly increased the excretion of a water load; estrogen reduced fluid exchange but did not alter the increased water excretion. Estrogen, in total dosages of 33.3 to 533 μg reduced the 6-hr drinking, while 16.6 and 25 μg did not. Food deprivation increased the 3-hr drinking response to NaCl, and 125, 250 or 500 μg estradiol, given 2 hr prior to the gavage significantly depressed this response. It is concluded that estrogen inhibition of the polyuricpolydipsic syndrome is due to a depression of water intake. (Endocrinology93: 925, 1973)

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