THE STRUCTURE OF THE T-CELL GAMMA-CHAIN GENE IN LYMPHOPROLIFERATIVE DISORDERS AND LYMPHOMA CELL-LINES
- 1 August 1986
- journal article
- research article
- Vol. 68 (2) , 592-594
Abstract
During the development of B and T cells, a number of genes undergo rearrangement. In this paper we have studied the structure of the T cell .gamma.-chain gene in primary lymphomas and cell lines derived from patients with lymphoma. Samples derived from patients with angioimmunoblastic lymphoadenopathy (AIL), Lennert''s lymphoma, and Hodgkin''s disease were also examined. TcR.gamma. was rearranged in all T cell lymphomas and B cell lymphoma cell lines. Rearrangement of the .gamma.-chain gene was also found in AIL, Lennert''s lymphoma, and four of eight cases of Hodgkin''s disease. These studies indicate that rearrangement of TcR.gamma. is a useful clonal marker but does not aid in the identification of cell lineage.This publication has 5 references indexed in Scilit:
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