CD1d-Restricted and TCR-Mediated Activation of V α 14 NKT Cells by Glycosylceramides
- 28 November 1997
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 278 (5343) , 1626-1629
- https://doi.org/10.1126/science.278.5343.1626
Abstract
Natural killer T (NKT) lymphocytes express an invariant T cell antigen receptor (TCR) encoded by the V α 14 and J α 281 gene segments. A glycosylceramide-containing α-anomeric sugar with a longer fatty acyl chain (C 26 ) and sphingosine base (C 18 ) was identified as a ligand for this TCR. Glycosylceramide-mediated proliferative responses of V α 14 NKT cells were abrogated by treatment with chloroquine–concanamycin A or by monoclonal antibodies against CD1d/V β 8, CD40/CD40L, or B7/CTLA-4/CD28, but not by interference with the function of a transporter-associated protein. Thus, this lymphocyte shares distinct recognition systems with either T or NK cells.Keywords
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