The Neurological and Metabolic Effects of Streptozotocin in the Cat

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Abstract
The ability of varying doses of streptozotocin to produce diabetes mellitus in cats was assessed. Doses up to and including 200mg/kg did not induce diabetes, but did impair the glucose tolerance of the animals. Certain neurological symptoms appeared with doses higher than 75 mg/kg, amongst which were parasympathetic actions such as decreased heart rate, defecation, pin point pupils and salivation. In addition, animals given 200 mg/kg showed additional symptoms of hind limb paralysis and hyporeflexia. A suggestion concerning the significance of these findings is given.

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