Intracellular analysis of potentiation of CA1 hippocampal synaptic transmission by phorbol ester application
- 1 January 1988
- journal article
- research article
- Published by Springer Nature in Experimental Brain Research
- Vol. 71 (3) , 588-596
- https://doi.org/10.1007/bf00248751
Abstract
(1) The effect of active and inactive phorbol esters on synaptic transmission and on membrane properties of CA1 pyramidal cells in hippocampus have been analyzed by intracellular recording. (2) 4β-phorbol-12,13 dibutyrate (βPDBu), but not the α-isomer, increased the firing probability, reduced the spike latency and enhanced the EPSP amplitude in response to synaptic activation. The effect was similar to the changes seen in long term potentiation. After αPDBu addition it was possible to elicit further enhancement by tetanization, but not after βPDBu administration. (3) A slowly developing hyperpolarization was seen after active phorbol ester application without apparent changes in the soma input resistance. (4) Active phorbol esters reduced the slow afterhyperpolarization (AHP) in these cells without affecting the intermediate AHP.Keywords
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